Ozempic is a medication that is used primarily to treat diabetes, but is also used by some doctors for weight loss. It is given as a once-weekly injection and has been found to help many patients lose excess weight. However, it should only be used under medical supervision and after a proper health assessment.(1)

Who Can Use Ozempic for Weight Loss?

Ozempic may be prescribed for individuals who:(2)

• Have obesity.
• Are overweight (BMI 27 or higher) and have a weight-related condition such as type 2 diabetes or high blood pressure.
• Do not have medical contraindications, which include:
  
  • A personal or family history of medullary thyroid cancer.
  • Multiple Endocrine Neoplasia type 2 (MEN2).
  • Allergy to any of its ingredients.

You should inform your doctor about any past or current health conditions, especially if you have a history of pancreatitis, severe stomach disorders (such as gastroparesis), or diabetic retinopathy. These conditions need to be carefully assessed before you start using Ozempic to ensure it is safe for you

How Much Weight Do You Lose with Ozempic?

You lose, on average, 15% of your body weight (around 16 kg) during two years of treatment with Ozempic. But it differs from individual to individual; some lose more, and others lose less. (3)

When Does Weight Loss Start With Ozempic?

The timing of weight loss varies from person to person, but in general, you may start losing weight within a few weeks of starting Ozempic. (4)

What Are the Expected Side Effects?

In general, Ozempic's common side effects are temporary and usually improve over time. (1) These may include:

• Nausea and vomiting
• Fatigue or weakness
• Diarrhea or constipation
• Bloating
• Headache
• Abdominal pain

In less common cases, Ozempic may cause more severe side effects that require prompt medical consultation, including:

• Pancreatitis: Symptoms include severe, persistent abdominal pain, which may be accompanied by nausea.
• Gallbladder issues: Symptoms include pain in the upper right abdomen, fever, and yellowing of the skin and eyes.
• Hypoglycemia (Low blood sugar): Signs include dizziness, shaking, sweating, and a rapid heartbeat.
• Kidney problems.
• Increased heart rate.
• Vision problems ( in people with type 2 diabetes).
• Depression.

How to Use Ozempic?

Ozempic comes as a pre-filled injection pen and should be taken as a subcutaneous injection once a week.(5)

Typical Dosage Schedule:

• Weeks 1–4: 0.25 mg once a week.
• Weeks 5–8: 0.5 mg once a week (this is the effective dose for many patients).
• After 4 more weeks:
  
  • If additional weight loss support is needed, the dose may be increased to 1 mg per week.
  • If further adjustment is required, the dose can be increased to a maximum of 2 mg per week after another 4 weeks, depending on the body's response and under medical supervision.

Note: The gradual increase in dosage allows the body to adjust to the medication and helps reduce digestive side effects, such as nausea and diarrhea.

Which Is More Effective: Ozempic or Mounjaro?

• Studies suggest that Mounjaro is more effective for weight loss.

• Mounjaro helps with an average weight loss of 15–21%, while Ozempic typically leads to around 15% weight loss.
• Ozempic has proven benefits in reducing the risk of heart-related complications and death in patients with cardiovascular disease, whereas Mounjaro’s effectiveness in this area is still being studied.(6)
• Whether you opt for Mounjaro or Ozempic, both require commitment to a healthy diet and exercise for the best results.

Thinking About Using Ozempic for Weight Loss?

Consult a specialist to determine if it's right for you and to learn how to use it safely. Book your appointment today with the Endocrinology Department.

References 

1. Ozempic.com - Ozempic
2. UCLA Health - Semaglutide, also known as Ozempic, for weight loss - what you need to know
3. Novomedlink - Wegovy® (semaglutide) injection 2.4 mg Official Physician Site
4. Mayo Clinic Diet - How fast does semaglutide kick in
5. Simple Online Pharmacy - What is the Ozempic Dosage for Weight Loss? | Simple Online Pharmacy‍
6. drugs.com - Mounjaro vs Ozempic: Which is right for you?